SAFETY INFORMATION

Indication and clinical use:

AKLIEF^® (trifarotene 50 mcg/g) cream is indicated for the topical treatment of acne vulgaris of the face and/or trunk in patients 12 years of age and older.¹

Safety and effectiveness have not been established in geriatric patients (≥65 years).

Contraindications:

Eczema or seborrheic dermatitis
Pregnancy or women planning a pregnancy

Most serious warnings and precautions:

For external use only, not for ophthalmic use
Pregnancy or planning a pregnancy: Rare reports of birth defects associated with topical retinoids during pregnancy. Women of childbearing potential should be informed of potential risks and use effective birth-control measures

Other relevant warnings and precautions:

Discontinue use if allergic/hypersensitivity reactions occur
Avoid contact with eyes, lips, angles of the nose, mucous membranes, abraded skin, open wounds, cuts, and eczematous or sunburned skin
Avoid use of other dermatologic medications and potentially irritating topical products that have a strong skin-drying effect and products with high concentrations of alcohol, astringents, spices, or limes
Non-comedogenic cosmetics should be used
Treatment area should not be covered with dressings or bandages
Weather extremes, such as wind or cold, may be more irritating
Exposure to excessive sunlight, including sunlamps, should be avoided or an effective sunscreen and protective clothing are recommended
Certain cutaneous signs and symptoms can be expected with use
Use of electrolysis, "waxing", and chemical depilatories for hair removal should be avoided
Caution when taking drugs with known photosensitizers
Avoid use on chest during breastfeeding

For more information:

Please consult the AKLIEF^® Product Monograph at https://pdf.hres.ca/dpd_pm/00054047.PDF for important information relating to adverse reactions, interactions, and dosing information, which have not been discussed in this advertisement.

The Product Monograph is also available by calling us at 1-800-467-2081.